Action of a chelate of zinc on trace metals in hypertensive rats

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Abstract
Prior studies show that a chelate of zinc (Na2Zn-CDTA), injected into Cd hypertensive rats, removed Cd and added Zn in kidneys and livers, with lowering of blood pressure. In order to ascertain oral effects, Cd-hypertensive rats were given either the chelate in water or deionized water for 200 days. In both cases there was less Cd and Zn found than in animals fed Cd, and hypertension regressed. Young rats were subjected to partial constriction of 1 renal artery and given Cd or Zn in water, or deionized water. After injection with the zinc chelate, transient lowering of blood pressure occurred. Amounts of Cd and Cu were lower in liver and in both the ischemic and the opposite kidney than in noninjected renal ischemic animals; Zn and Cr were unaffected. The contracted kidney lost Zn and Cu, but not Cd or Cr. Cd hypertension in rats may be reversible when exposure to Cd is discontinued, and its mechanism differs from that of renal ischemic hypertension.

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