Bacterial ADP‐Ribosylating Toxins: Molecular Structures and Signal Transducing Functions

Publisher Website
Google Scholar
Abstract
Mono‐ADP‐ribosylation is a posttranslational modification of proteins employed by a variety of bacterial ADP‐ribosylating toxins to modify the metabolism of target cells. The ADP‐ribosyltransferases of bacterial toxins, in general, use NAD as a substrate for covalent modification by ADP‐ribose to certain GTP‐binding proteins (G proteins) as signal transducers resulting in altered enzymatic activity of the membrane enzymes as effectors. Such a mechanism has the potential of being of importance in the physiological regulation of cellular metabolism, particularly if the process is reversible. These ADP‐ribosylating toxins are characterized in Table 1.