An endothelial cell-derived growth factor.
Open Access
- 1 May 1980
- journal article
- research article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 85 (2) , 467-472
- https://doi.org/10.1083/jcb.85.2.467
Abstract
Cell-free plasma-derived serum (PDS) is deficient in the platelet-derived growth factor and will not support the growth of 3T3 cells, fibroblasts, or smooth muscle cells. However, when PDS-containing medium is preincubated with endothelial cells, the medium becomes modified so that it will support growth. The activity produced by the endothelial cells results from a polypeptide of 10,000 to 30,000 daltons which has several features that differ from those of the platelet-derived growth factor, including heat instability and lack of adsorption to CM Sephadex.Keywords
This publication has 26 references indexed in Scilit:
- Stimulation of endothelial cell proliferation by precursors of thymidylateJournal of Cellular Physiology, 1979
- Platelet factors and the human vascular wallAtherosclerosis, 1978
- Factors influencing endothelial cell proliferation in vitroJournal of Cellular Physiology, 1978
- Partial purification and characterization of platelet factors stimulating the multiplication of normal human glial cellsExperimental Cell Research, 1977
- Human fibroblast conditioned media contains growth‐promoting activities for low density cellsJournal of Cellular Physiology, 1977
- Growth Factors in Mammalian Cell CultureAnnual Review of Biochemistry, 1976
- A platelet factor stimulating human normal glial cellsExperimental Cell Research, 1976
- Isolation and characterization of revertant cell lines. II. Growth control of a polyploid revertant line derived from SV40‐transformed 3T3 mouse cellsJournal of Cellular Physiology, 1973
- Some characteristics of a factor stimulating skin epithelial cell growth in vitroExperimental Cell Research, 1973
- The initiation of cell division in a contact‐inhibited mammalian cell lineJournal of Cellular and Comparative Physiology, 1965