Effects of Ca2+ entry blockers on kainate‐induced changes in extracellular amino acids and Ca2+ in vivo
- 1 January 1987
- journal article
- research article
- Published by Wiley in Journal of Neuroscience Research
- Vol. 18 (2) , 341-344
- https://doi.org/10.1002/jnr.490180211
Abstract
The effect of organic Ca2+ channel blockers and Co2+ on kainate-induced in 45Ca2+ efflux and amino acid release was studied in the rabbit hippocampus with the dialysis-perfusion technique. Administration of 1 mM kainate caused a transient, 50% drop of extracellular Ca2+. This effect was insensitive to 100 μM flunarizine or verapamil, 10 μM nimodipine, and 6 mM CoCl2. The organic Ca2+ entry blockers did not significantly influence kainate-induced changes in extracellular amino acid, whereas Ca2+ affected both basal and kainic acid stimulated release of amino acids. These results indicate that kainate-regulated Ca2+ ionophores differ from Ca2+ channels in peripheral tissues in terms of sensitivity to Ca2+ entry inhibitors.Keywords
This publication has 15 references indexed in Scilit:
- NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neuronesNature, 1986
- Extracellular calcium in the hippocampus of unanesthetized rabbits monitored with dialysis-perfusionJournal of Neuroscience Methods, 1986
- Effects of Kainic Acid on Brain Calcium Fluxes Studied In Vivo and In VitroJournal of Neurochemistry, 1986
- Kainic acid responses and toxicity show pronounced Ca2+ dependenceBrain Research, 1985
- N-Methylaspartate-Evoked Liberation of Taurine and Phosphoethanolamine In Vivo: Site of ReleaseJournal of Neurochemistry, 1985
- A role for taurine in the maintenance of homeostasis in the central nervous system during hyperexcitation?Neuroscience Letters, 1984
- Effects of In Vivo Administration of Kainic Acid on the Extracellular Amino Acid Pool in the Rabbit HippocampusJournal of Neurochemistry, 1983
- Kainate, N-methylaspartate and other excitatory amino acids increase calcium influx into rat brain cortex cells in vitroNeuroscience Letters, 1983
- The Suppression of Stimulus-Evoked Release of Amino Acid Neurotransmitters from Synaptosomes by VerapamilJournal of Neurochemistry, 1983
- High performance liquid chromatographic determination of subpicomole amounts of amino acids by precolumn fluorescence derivatization with o-phthaldialdehydeAnalytical Chemistry, 1979