INFLUENCE OF PROSTAGLANDIN-A1, PROSTAGLANDIN-E1, PROSTAGLANDIN-E2, AND PROSTAGLANDIN-F2-ALPHA ON RENAL BLOOD-FLOW AND PLASMA-RENIN ACTIVITY - INVESTIGATIONS IN CHRONICALLY INSTRUMENTED CONSCIOUS DOGS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 5  (2) , 57-67
Abstract
The effects of different prostaglandins (PG) on serial determinations of renal blood flow (RBF), mean arterial blood pressure (MABP), renal vascular resistance (RVR) and renin release were investigated in the conscious, chronically instrumented dog. Female beagle dogs (6) were implanted with an electromagnetic flow probe and an inflatable pneumatic cuff around the left renal artery 2 mo. after right-sided nephrectomy; a catheter was inserted into the aorta above the renal artery. In repeated experiments, different PG (PGA1, PGE1, PGE2 and PGF2.alpha.) were infused above the renal artery at increasing doses (infusion time 15 min, doses 0.03-1.0 .mu.g min-1 kg-1). Lower and medium doses induced an increase of RBF, which returned to or were slightly below control levels with higher doses. PGA1 appeared to be the most potent vasodilator with a significant hypotensive activity and the greatest augmentation of RBF. Renin release was most pronounced by PGA1.