Local Antifertility Effect of Luteinizing Hormone-Releasing Hormone (LRH) in the Rat: Mechanism of Action

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Abstract
The administration of luteinizing hormone-releasing hormone (LRH) into one horn of the uterus at 0900 h on D5 of pregnancy produces a 96% reduction in the number of zona-encased blastocysts recovered between 0915 and 1300 h on D5. The number of blastocysts recovered within this time period also decreased; only one blastocyst was recovered from the LRH-treated horn at 1300 h while 26 were flushed from the horns injected with saline. The results of this study suggest that LRH causes a premature disassociation of the zona from the blastocyst allowing early adherence to the uterine wall. This asynchronous attachment results in disruption of the ensuing pregnancy.