A Method for Evaluating the Effect of Pharmacological Substances on Mucociliary Activity in Vivo
- 1 January 1982
- journal article
- research article
- Published by Taylor & Francis in Acta Oto-Laryngologica
- Vol. 93 (1-6) , 151-159
- https://doi.org/10.3109/00016488209130866
Abstract
A test model for in vivo studies of the effect of pharmacological substances on mucociliary activity in the rabbit maxillary sinus is presented. The method permits administration of pharmacological substances and recording of the mucociliary activity under conditions that mimic the physiological situation very closely. The test substances are given intra-arterially. Using a photoelectric technique the mucociliary activity is recorded from a small and limited area of the mucous membrane. There is minimal exposure to external stimuli since normal sinus ventilation is retained. Various factors which may influence the results, e.g., the anesthesia, movements from cardiac and respiratory activity and the volumes and injection velocities of test doses, are analyzed and discussed. When the animal model was tested with serotonin, ATP, and cholinergic and adrenergic agents [methacholine, acetylcholine, pilocarpine, epinephrine, orciprenaline and norepinephrine], it was reliable. It permitted easy detection of changes in the mucociliary activity and gave reproducible results.This publication has 30 references indexed in Scilit:
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