Serum from Monkeys with Histories of Fetal Wastage Causes Abnormalities in Cultured Rat Embryos

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Abstract
Rat embryos in the mid-head-fold stage were cultured on female monkey serum for 48 h. On the basis of embryo response, the investigators, with no knowledge of the donors'' reproductive histories, correctly identified the serum from 2 high-risk breeders among 18 rhesus monkeys and the serum from 12 of 14 high-risk breeders among 26 pig-tailed monkeys as teratogenic. Of the embryo response parameters, abnormality type and frequency were more closely correlated with donor reproductive histories than embryo protein content or somite number.