Chemical N-Glycosylation by Asparagine under Integrated Microfluidic/Batch Conditions
- 2 June 2009
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2009 (10) , 1571-1574
- https://doi.org/10.1055/s-0029-1217343
Abstract
An integrated microfluidic/batch system was applied to the chemical N-glycosylation by the asparagine amide group, a key glycosyl bond-formation reaction in the synthesis of N-glycopeptides. By applying the advantageous features of microfluidic conditions, that is, efficient mixing and rapid heat transfer, the GlcNTrocβAsn and the Fucα(1-6)GlcNTrocβAsn fragments were efficiently prepared.Keywords
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