SEASONAL-VARIATION IN CELL-MEDIATED-IMMUNITY OF CLINICALLY NORMAL DOGS

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 8  (3) , 318-326
Abstract
A whole blood lectin-induced lymphocyte stimulation test, using Con [concanavalin] A and PHA [phytohemagglutinin] was used to assess the cell-mediated immune status of 52 beagle dogs over 16 mo. The data indicated the presence of a seasonal variation in immune response, with the peak estimated to be in July and an estimated trough in Jan. The relative amplitudes around the mean, for the 2 mitogens, were about 50%, so that the responses in lymphocyte division ranged from 50-150% of the mean during the year. The possible implications of this finding for human health are discussed.