Systemic Anaphylaxis in the Human Being

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Abstract
THE term "anaphylaxis" was introduced by Poitier and Richet1 to describe the profound shock with subsequent death produced in some dogs upon reinjection of the poison of the sea anemone. The occurrence of a fatal response to repeat injection rather than a demonstration of immunity or prophylaxis to the foreign protein prompted the designation anaphylaxis. The clinical manifestations of the anaphylactic syndrome are entirely due to the action of diverse chemical mediators released with great rapidity by antigen activation of a discrete number of target cells previously sensitized by interaction with antibody; the chemical mediators — histamine, slow reacting substance . . .