Application of High Pressure Induced by Water-Freezing to the Direct Catalytic Asymmetric Three-Component List−Barbas−Mannich Reaction
- 21 August 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (37) , 11208-11209
- https://doi.org/10.1021/ja0372513
Abstract
High pressure induced by water-freezing has been successfully applied to the direct catalytic asymmetric-three component List−Barbas−Mannich reaction, in which higher yield and better enantioselectivity can be realized than those from the reaction at room temperature under 0.1 MPa.Keywords
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