Inhibition of lipoprotein lipase by the receptor‐binding domain of apolipoprotein E
- 17 July 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 251 (1-2) , 250-252
- https://doi.org/10.1016/0014-5793(89)81464-4
Abstract
A synthetic peptide (residues 139–153) corresponding to the receptor‐binding domain of apolipoprotein E (ApoE) was tested for lipoprotein lipase (LPL) inhibitory properties. In systems using both natural and synthetic substrates, inhibition of LPL was observed. Using the synthetic substrate, 50% inhibition was observed at 50 μM while high concentrations completely inhibited LPL activity. These studies suggest an additional functional role for the receptor‐binding domain of ApoE — modulation of LPL activity.Keywords
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