THE ANTICOAGULANT AND ANTILYMPHOMA PROPERTIES OF ARSENIC AZOPROTEINS

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Abstract
Experiments in this paper have shown that 4-arsonophenylazoproteins possess marked anticoagulant activity both in vivo and in vitro. Two acidic azoproteins that are devoid of arsenic[long dash]namely 4-carboxyphenylazoprotein and 4-sulfono-phenylazoprotein[long dash]have marked anticoagulant effects in vitro, but they had no inhibitory action against cells of Lymphoma 6C3HED in vivo, even when they were given to mice in maximum tolerated amounts. The essential part played by arsenic in the antilymphoma activity of arsenic azoproteins is further emphasized by the action of dimercaprol (BAL) in preventing the antilymphoma effects of 4-arsonophenylazo-protein on Lymphoma 6C3HED cells in vivo.