Experimental Infection of Subpopulations of Human Peripheral Blood Leukocytes by Herpes Simplex Virus

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Abstract
Results from examination of peripheral blood leukocytes from 5 subjects, 3 with antibody to HSV [herpes simplex virus] and 2 without, showed that HSV type 1 may replicate in mitogen-stimulated T [thymus derived] and B [bone marrow derived] lymphocytes and in continuous lymphoblastoid cell lines derived from B or T cells. Significant replication was also noted in monocytes from each subject but not in polymorphonuclear leukocyte subpopulations. Replication in monocytes was dependent on certain conditions of culture and viral inoculation. Only adherent cells cultured for 72-h prior to infection produced significant yields of virus.