Tumor Susceptibility in Rats: Role of Infantile Manipulation and Later Exercise

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Abstract
Rat pups were removed from the nest briefly each day during the first week of life. Later experience with forced ambulation before and after implantation with the Walker carcinoma 256 was assessed for its effect on tumor size and survival of the animal. Exercise slowed tumor growth. Change in survival time resulting from exercise was not demonstrated in non-manipulated rats. Among manipulated animals, the group exercised both before and after implantation lived longer than rats exercised only after implantation. Infantile manipulation enhanced the exercise effect on tumor growth, and delayed mortality.