The Mode of Action of Nosiheptide (Multhiomycin) and the Mechanism of Resistance in the Producing Organism
- 1 September 1981
- journal article
- research article
- Published by Microbiology Society in Microbiology
- Vol. 126 (1) , 185-192
- https://doi.org/10.1099/00221287-126-1-185
Abstract
The mode of action of nosiheptide (multhiomycin) on bacterial protein synthesis is closely similar to that of thiostrepton. Both antibiotics inhibit functions of elongation factors Tu and G and greatly reduce the synthesis of guanosine penta- and tetraphosphates in response to stringent factor. Furthermore, the actinomycetes which produce these antibiotics defend themselves against their products in similar fashion. This involves specific pentose-methylation of 23S ribosomal RNA.This publication has 7 references indexed in Scilit:
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