EFFECT OF ORGAN EXTRACTS AND THEIR FRACTIONS ON ACETYLCHOLINE SYNTHESIS
- 1 February 1947
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 148 (2) , 417-423
- https://doi.org/10.1152/ajplegacy.1947.148.2.417
Abstract
Blood serum and animal tissues contain both substances that increase acetylcholine synthesis and substances that decrease it. Human blood serum and water extracts of various tissues contain substances that increase acetylcholine synthesis. These substances are in part non-dialyzable (proteins, lipoproteins) and in part dialyzable, many of them heat stable and organic. Ether extracts of serum and various tissues contain factors that decrease acetyl-choliue synthesis. For some of the depressor effects fatty acids are responsible. Tissue fractions containing cholesterol and cholesterol esters do not modify the amts. of acetylcholine synthesized, cephalin decreases the synthesis and lecithin increases it.Keywords
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