Decline in Male Mouse Pheromone with Age

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Abstract
An age-related decline in urinary-borne pheromone was found in male C57BL/6J mice aged 2-30 mo. Pheromone activity, estimated by bioassay, declined sharply after .apprx. 10 mo. of age. Two other strains of mice tested (DBA/2J and CBA/HT6J) also appeared to show an age-related decline in pheromone activity. Within each strain, pheromone activity was consistently similar to or higher than that of the C57BL/6J male mice. The DBA/2J and BALB/cWt strains appeared to be high pheromone producers, and the C57BL/6J and CBA/HT6J strains, low producers. The decline with age in male mouse pheromone activity is apparently reported for the 1st time. This decline appears to be synchronized with the well-defined loss of reproductive function in female mice.

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