Immunological Tolerance to Many Self Epitopes may be Unnecessary
- 31 August 1990
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 32 (3) , 293-296
- https://doi.org/10.1111/j.1365-3083.1990.tb02923.x
Abstract
The demonstration of the existence of antigenic mimicry suggests that immunological tolerance to self antigens may be an insufficient basis for distinguishing self from non-self. However, some data suggest that even in the absence of tolerance most self epitopes would not immunize the host and that tolerance to all self epitopes may, therefore, not be necessary for the prevention of autoimmune disease.This publication has 10 references indexed in Scilit:
- Peripheral tolerance to allogeneic class II histocompatibility antigens expressed in transgenic mice: evidence against a clonal-deletion mechanism.Proceedings of the National Academy of Sciences, 1989
- Developmental Biology of T Cell ReceptorsScience, 1989
- Are Invertebrates Capable of Anticipatory Immune Responses?Scandinavian Journal of Immunology, 1989
- The Flip Side of Tumor ImmunityArchives of Surgery, 1989
- Unresponsiveness to a foreign antigen can be caused by self-toleranceNature, 1988
- Immunostimulation of the Lymphodependent Phase of Neoplastic GrowthJNCI Journal of the National Cancer Institute, 1977
- THE ROLE OF AFFERENT LYMPHATICS IN THE REJECTION OF SKIN HOMOGRAFTSThe Journal of Experimental Medicine, 1968
- DEMONSTRATION OF RESISTANCE AGAINST METHYLCHOLANTHRENE-INDUCED SARCOMAS IN THE PRIMARY AUTOCHTHONOUS HOST1960
- Fate of Vascularized and Nonvascularized Subcutaneous Homografts in MiceJNCI Journal of the National Cancer Institute, 1954
- Encephalomyelitis in the Rat Following Intracutaneous Injection of Central Nervous System Tissue with AdjuvantExperimental Biology and Medicine, 1952