Potentiation of Hepatotoxicity by Ethanol in Galactosamine‐induced Hepatitis in Rats: Role of Propylthiouracil Protection

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Abstract
Chronic ingestion of ethanol (5 g/kg per day) for 6 wk increased the hepatotoxicity of a single injection of D-galactosamine (330 mg/kg) in rats. Plasma transaminases, alkaline phosphatase, .gamma. glutamyl transpeptidase and sulfobromophthalein retention were consistently high in alcohol-fed rats compared to sucrose-fed controls, 25 h after galactosamine administration. Liver histology in sucrose-fed rats revealed typical inflammatory changes and cytoplasmic vacuolation without cell necrosis was seen. Propylthiouracil treatment had no beneficial or protective effect in alcohol-fed rats in this animal model of hepatitis.