Solanum alkaloids as inhibitors of enzymatic conversion of dihydrolanosterol into cholesterol.
- 1 January 1987
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 35 (10) , 4321-4323
- https://doi.org/10.1248/cpb.35.4321
Abstract
The effects of several solanum steroidal alkaloids on cholesterol biosynthesis from 24,25-dihydrolanosterol by 10000 .times. g supernatant fluid of rat liver were examined. Solacongestidine (I), solafloridine (II) and solasodine (III) (40 .mu.M each) exhibited considerable inhibitory effects (59, 51, 37% inhibition, respectively) on the synthesis of cholesterol from [24,25-3H]-24,25-dihydrolanosterol (18 .mu.M). The biological importance of the inhibitory properties of the steroidal alkaloids is discussed.This publication has 4 references indexed in Scilit:
- Synthesis of lanosterol analogs with lengthened side chains and their effects on cholesterol biosynthesis from lanosterol.CHEMICAL & PHARMACEUTICAL BULLETIN, 1984
- Effects of azasteroids on growth and development of the free-living stages of Nippostrongylus brasiliensis and Nematospiroides dubiusComparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1984
- Effects of 25-azasteroids on development and reproduction of the southwestern corn borer Diatraea grandiosella DyarJournal of Insect Physiology, 1982
- Effects of lanosterol analogs on cholesterol biosynthesis from lanosterol.CHEMICAL & PHARMACEUTICAL BULLETIN, 1981