Cerebral ischemia-reperfusion injury and adhesion

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Abstract
The adhesion and migration of neutrophils are orchestrated by several classes of cell surface glycoproteins. These include the leukocyte integrins(CD11/CD18), the immunoglobulin supergene family [intercellular adhesion molecule-1 (ICAM-1); vascular cell adhesion molecule-1 (VCAM-1)], and the selectins (L-, P-, and E-selectin).4 Studies employing monoclonal antibodies (MAbs) directed at specific members of these various pathways have been instrumental in demonstrating the importance of neutrophils in ischemia-reperfusion injury. In the heart, studies by Simpson et al.5 (anti-CD11b) and Seewaldt-Becker et al.6 (anti-CD11a, anti-CD18, anti-ICAM-1) were among the first to demonstrate that MAbs directed against either leukocyte or endothelial cell adhesion glycoproteins were effective in limiting the myocardial necrosis that developed in response to an ischemia-reperfusion protocol. Efficacy has also been demonstrated for MAbs administered just before reperfusion directed against the following molecules: L- …