REGIONAL MEASUREMENTS OF BLOOD-FLOW IN EXPERIMENTAL RG-2 RAT GLIOMAS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 43  (7) , 3362-3367
Abstract
Regional measurements of bood flow (F) were performed in transplanted intracerebral RG-2 rat gliomas using [14C]iodoantipyrine, Kety-Schmidt blood flow equations and quantitative autoradiography. Twenty-nine intracranial tumors in 10 rats were analyzed by location; 18 intraparenchymal, 7 meningeal, 2 third-ventricular, and 2 fourth-ventricular tumors were studied. For all tumors, averaged mean F was 91 .+-. 33 (SD) ml/hg per min. In all but 1 tumor, mean F was intermediate between normal cortex and corpus callosum values. There was moderate regional variation: averaged mean F was lower in tumor center (78 .+-. 47 ml/hg per min) than in tumor periphery (93 .+-. 30 mml/hg per min). Within individual tumors, F showed moderate variation which correlated to some extent with histological features; a regional F of < 10 ml/hg per min was observed in only 1 tumor within an area of necrosis. F in regions of brain imediately surrounding the tumor was higher than in tumor periphery. Blood flow to RG-2 tumors seems unlikely to limit drug delivery any more than to normal brain, and the consistent levels from tumor to tumor and within individual tumors make the RG-2 model an excellent one which to study drug delivery in experimental brain tumors.

This publication has 1 reference indexed in Scilit: