Histopathological observations in experimental cryptococcosis caused by a hypha-producing strain ofCryptococcus neoformans(Coward strain) in mice

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Abstract
Three distinct types of lesions were recognizable viz: histiocytic granulomata; tuberculoid granulomata with central necrosis surrounded by epithelioid cells and micro-abscesses. The inflammatory reaction was most severe with hyphal fragments and small, round or oval forms; it tended to diminish when larger round cells appeared and capsules increased in thickness. Large cells with wide capsules were not associated with any significant inflammatory reaction.

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