Distribution and elimination of 2-[14C]-acetone in mice after inhalation exposure.

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Abstract
The tissue distribution and elimination of the industrial solvent acetone and its metabolic radioactive fragments were studied in mice after exposure to .apprx. 1200 mg/m3 (500 ppm) 2-[14C]acetone vapor. The tissue concentrations of acetone reached steady-state plateaus within 6 h of exposure. In the adipose tissue the maximal concentration was .apprx. 1/3 that in the highly perfused nonadipose tissues, in which acetone was evenly distributed. The contents of radioactivity also reached a plateau within 6 h of exposure in all tissues except the liver and brown adipose tissue. In these tissues the radioactivity increased during exposures up to 24 h. Prolonging the exposure time from 6 h to 6 h/day for 3 and 5 consecutive days gave no, or only a small, additional accumulation of radioactivity in all tissues except adipose tissues. The half-times of acetone after 6 h of exposure were 2-5 h in all tissues. Almost equal amounts of acetone were excreted via the lungs unmetabolized or metabolized to CO2. In all tissues endogenous levels of acetone were reached within 24 h after exposure. Acetone did not accumulate after prolonged or repeated exposure to concentrations of 1200 mg/m3.

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