Creatine Kinase and Hexose Phosphate Isomerase Activity in Skeletal Muscles of Healthy Male Adults

Publisher Website
Google Scholar
Abstract
Creatine kinase (CPK) and hexose phosphate isomerase (PHI) activities were measured in surgically obtained skeletal muscle samples of healthy adult men. Median values of 4200 for CPK and 275 for PHI (U[units]/g wet wt, 37.degree. C) were found. Duplicate determinations on 7 samples divided and treated separately gave a very good reproducibility. There was a significant relationship between activity of the 2 enzymes (r [correlation coefficient] = +0.798, P < 0.001). Mean activity levels for both enzymes were higher in vastus medialis quadricipitis and triceps brachii, caput longum muscles, than in vastus lateralis quadricipitis and in deltoideus muscles. PHI frequency distribution was not of the normal type but probably bimodal, suggesting muscle types with lower and higher glycolytic rate in man.