Sulphobromophthalein retention in gout and asymptomatic hyperuricaemia.

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Abstract
A high incidence of abnormal results in the sulphobromophthalcin (BSP) retention test was found in a group of patients suffering from gout and another with asymptomatic hyperuricemia. Fifty-five of 73 (75%) gouty subjects and 12 of 16 (75%) with asymptomatic hyperuricemia showed more than 5% retention of BSP at 45 min. compared with 6 of 30 (20%) controls. Though these results may have been influenced by the effects of obesity, alcohol intake, and age, significant differences are sill apparent after allowances are made for these factors. Possible mechanisms for this apparent association are discussed. Attention is drawn to certain inaccuracies in the BSP test as commonly performed, and in particular in the interpretation of results in obese subjects.