The Effect of Clomiphene Citrate on Different Sperm Parameters and Serum Hormone Levels in Preselected Infertile Men: A Controlled Double‐Blind Cross‐Over Study

Open Access
Publisher Website
Google Scholar
Abstract
To try to clarify the often supposed stimulating effect of clomiphene citrate on spermatogenesis a controlled double-blind cross-over trial was used. Pre-selected normogonadotropic infertile men (30) were given 50 mg clomiphene citrate daily or placebo in a double-blind cross-over fashion for 3 mo., each treatment period being separated by 3-4 mo. On clomiphene treatment the median sperm count increased from 13.3 to 28.7 million/ml (P < 0.001). During the placebo treatment schedules the median sperm count remained unchanged (P > 0.05). The increases of follitropin, lutropin, testosterone and estradiol were highly significant (P < 0.001) during the clomiphene treatment but during placebo treatment the median hormone levels did not change (P > 0.05). Three pregnancies occurred due to clomiphene treatment and 1 occurred during placebo treatment.