Primary Aldosteronism and Hypertensive Disease
Top Cited Papers
- 1 August 2003
- journal article
- research article
- Published by Wolters Kluwer Health in Hypertension
- Vol. 42 (2) , 161-165
- https://doi.org/10.1161/01.hyp.0000079505.25750.11
Abstract
Recent studies in hypertensive populations that have used the serum aldosterone (SA) to plasma renin activity (PRA) ratio as a screening test have demonstrated a high prevalence of primary aldosteronism (PA). This frequency is higher than that previously described when hypokalemia was used as a screening tool. However, other factors, such as the characteristics of hypertensive disease, could also influence the prevalence of PA. We studied 609 essential hypertensive patients, classified according to the Joint National Committee VI (JNC VI), in 3 different stages depending on the severity of their hypertensive disease. We measured SA and PRA and calculated the SA-PRA ratio for all patients. An SA-PRA ratio >25 was detected in 63 of 609 patients, and the fludrocortisone test confirmed the PA diagnoses in 37 of 609 (6.1%) cases. PA prevalence according to hypertension stage was as follows: stage 1, 6 of 301 cases (1.99%); stage 2, 15 of 187 cases (8.02%); and stage 3, 16 of 121 cases (13.2%). PA patients were...Keywords
This publication has 20 references indexed in Scilit:
- Drug Effects on Aldosterone/Plasma Renin Activity Ratio in Primary AldosteronismHypertension, 2002
- Clinical characteristics of primary aldosteronism: its prevalence and comparative studies on various causes of primary aldosteronism in Yokohama Rosai HospitalBiomedicine & Pharmacotherapy, 2000
- High prevalence of primary aldosteronism in the Tayside hypertension clinic populationJournal of Human Hypertension, 2000
- Aldosterone-producing adenoma without hypertension: a report of two casesActa Endocrinologica, 1999
- Primary AldosteronismNew England Journal of Medicine, 1998
- The Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood PressureArchives of internal medicine (1960), 1997
- HIGH INCIDENCE OF PRIMARY ALDOSTERONISM IN 199 PATIENTS REFERRED WITH HYPERTENSIONClinical and Experimental Pharmacology and Physiology, 1994
- Diagnosis under Random Conditions of All Disorders of the Renin-Angiotensin-Aldosterone Axis, Including Primary HyperaldosteronismJournal of Clinical Endocrinology & Metabolism, 1991
- Plasma aldosterone-plasma renin activity ratio A simple test to identify patients with primary aldosteronismActa Endocrinologica, 1986
- Value of renin measurement, saralasin test, and acebutolol treatment in hypertensionKidney International, 1979