Borohydride Reductions in Dichloromethane: A Convenient, Environmentally Compatible Procedure for the Methylation of Amines
- 1 July 1995
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 25 (14) , 2061-2069
- https://doi.org/10.1080/00397919508015887
Abstract
The combination of zinc chloride and sodium borohydride in dichloromethane is used to effect reductive aminations of formaldehyde with a variety of primary and secondary amines containing potentially acid-sensitive functional groups in good to excellent yields.Keywords
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