THYROID DEFICIENCY AND CELL DEATH IN THE RAT CEREBELLUM DURING DEVELOPMENT

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Abstract
The [3H]-DNA content of the cerebellum remained constant from 4 h to 8-9 days after the administration of [3H]-thymidine both to normal rats at 6 and 12 days of age and to thyroid deficient rats at 6 days. When [3H]-thymidine was given to 12 day old thyroid deficient rats, a progressive decrease in the cerebellar content of [3H]-DNA was observed during the first 4 days after the injection. A markedly elevated pyknotic index was shown in the internal granular layer of the 12 day old hypothyroid cerebellum, which was consistent with there being an increased death of newly formed and differentiating granule cells in thyroid deficiency towards the end of the 2nd wk of postnatal life.