Oral granular cell myoblastoma: an immunohistochemical study

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Abstract
Immunoperoxidase staining for a variety of antigens was performed on 15 cases of granular cell myoblastoma occurring within the oral tissues. All tumors gave intense intracytoplasmic granular staining for a CEA[carcinoembryonic antigen]-related antigen with 1 rabbit antiserum to CEA (Dakopatts); all were negative with a sheep antiserum to CEA (Seward). None of the tumors were positive for lysozyme, .alpha.1 antitrypsin or cathepsin B; 12 lesions gave a granular reaction for cathepsin D. All granular cells showed a weak reaction for actin in contrast to the strong cytoplasmic staining found in smooth and striated muscle, and muscle-derived tumors.

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