Synthesis and biological activities of chloroethylurea, methylurea, and nitrosourea analogs of N-deacetylmethylthiocolchicine
- 1 December 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 23 (12) , 1440-1442
- https://doi.org/10.1021/jm00186a028
Abstract
A series of urea and nitrosourea analogs of N-deacetylmethylthiocolchicine was synthesized; their antineoplastic and antiviral activities were evaluated. The objective for combination of 2 active moieties, such as thiocolchicine and nitrosourea, into 1 molecule was the generation of compounds with potential improved biological and pharmacological properties. The ED50 for the analogs was 1.6, 1.2, 3.3, and 1.8 .times. 10-8 M for [mouse leukemia] L1210 cells and 3.0, 2.7, 2.9, and 2.6 .times. 10-8 M for [mouse sarcoma] S-180 cells, respectively. The synthesis and cytotoxic and antiviral properties of these compounds are discussed.This publication has 5 references indexed in Scilit:
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