Changes in computerized videokeratography induced by artificial tears

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Abstract
Purpose: To analyze the effect of several standard artificial tear preparations on computerized videokeratograhic measurements. Setting: Cullen Eye Institute, Baylor College of Medicine, Department of Ophthalmology, Houston, Texas, USA. Methods: We evaluated one eye each in 18 normal volunteers. Using the EyeSys Corneal Analysis System™ (EyeSys Technologies), we obtained corneal topographic measurements at baseline and 0.5, 1, 2, 3, 4, 5, 6, 8, and 10 minutes after instillation of the following preparations: balanced salt solution, Tears Naturale®II, Tears Naturale Free®, Cellufresh®, Celluvisc®, HypoTears®, and HypoTears®PF. We analyzed changes in curvature of the keratographic rings at radii 1 to 5 mm and changes in keratometric-equivalent astigmatic power and meridian. Results: All preparations except HypoTears and Tears Naturale II induced statistically . significant, time-dependent changes in mean corneal power in the central 5 mm corneal zone compared with baseline measurements (P < .05). The relationship between change in dioptric power over time varied with preparation type and was nonlinear in nature. In all cases, the mean induced change was ≤.5 diopter. Except for Celluvisc, tear administration produced minimal changes in the values of corneal astigmatic power or meridian. Conclusion: When performing serial measurements of mean corneal power, the greatest consistency was achieved with no tears or with instillation of HypoTears or Tears Naturale II.

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