ALCOHOLISM, NONPRESCRIPTION DRUGS AND HEPATOTOXICITY - THE RISK FROM UNKNOWN ACETAMINOPHEN INGESTION
- 1 January 1981
- journal article
- research article
- Vol. 76 (6) , 530-533
Abstract
An alcoholic patient developed severe hepatitis and renal failure after ingesting the contents of a 300 ml bottle of Nyquil for its ethanol content. This illness was presumably related to the 6 g of acetaminophen contained in this nonprescription preparation. Although hepatic damage with or without renal failure is usually described after a massive overdose of acetaminophen, the changes in drug metabolism induced by chronic ethanol consumption may increase the risk for acetaminophen toxicity. The large number of nonprescription acetaminophen-ethanol preparations available should be considered in evaluating an alcoholic patient seen with acute hepatic and renal dysfunction.This publication has 4 references indexed in Scilit:
- Apparent Potentiation of Acetaminophen Hepatotoxicity by AlcoholAnnals of Internal Medicine, 1980
- Increased paracetamol-induced hepatotoxicity after chronic alcohol consumptionBiochemical and Biophysical Research Communications, 1979
- Chronic Excessive Acetaminophen Use and Liver DamageAnnals of Internal Medicine, 1977
- Ethanol Increases Hepatic Smooth Endoplasmic Reticulum and Drug-Metabolizing EnzymesScience, 1968