Hemin: An Inhibitor of Erythroid Cell Ribonuclease
- 13 December 1968
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 162 (3859) , 1287
- https://doi.org/10.1126/science.162.3859.1287
Abstract
Hemin, in concentrations which stimulate protein synthesis and stabilize polyribosomes in reticulocytes, is a potent inhibitor of ribonuclease activity in the erythroid cell. This may offer a partial explanation for the way in which hemin acts to accelerate globin synthesis and thus synchronize the synthesis of hemin and globin in the maturing erythroid cell.Keywords
This publication has 9 references indexed in Scilit:
- Factors affecting the rate of protein synthesis in lysate systems from reticulocytesArchives of Biochemistry and Biophysics, 1968
- Stimulation of globin synthesis by RNA purified from reticulocyte supernatant fractionArchives of Biochemistry and Biophysics, 1968
- Membrane-Bound Ribonucleic Acid in Mammalian Erythroid Cells*Biochemistry, 1967
- Control of reticulocyte polyribosome content and hemoglobin synthesis by hemeBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1966
- Heme Stimulation of Globin Synthesis in a Cell Free SystemScience, 1966
- Dependence of Polyribosome Structure in Reticulocytes on Iron ; Implication on the Tape Theory of Haemoglobin SynthesisNature, 1965
- The effect of hemin on the synthesis of globinBiochemical and Biophysical Research Communications, 1965
- Initiation of hæmoglobin synthesis in cell-free systemsJournal of Molecular Biology, 1964
- HEMOGLOBIN SYNTHESIS IN RABBIT RETICULOCYTES IN VITROJournal of Biological Chemistry, 1956