The treatment of passively transferred experimental myasthenia with anti‐idiotypic antibodies
- 1 May 1986
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 36 (5) , 622
- https://doi.org/10.1212/wnl.36.5.622
Abstract
Experimental autoimmune myasthenia gravis (EAMG) was induced in chickens by passive transfer of a monoclonal antibody (mcAb) specific for the cholinergic binding site of the acetylcholine receptor (AChR). Specific anti-idiotypes raised in rabbits against this antisite mcAb (5.5) were demonstrated to prevent the induction of EAMG by a subsequent injection of mcAb 5.5. Also, administration of anti-idiotypes against mcAb 5.5 to chickens in which EAMG has been induced by mcAb 5.5 led to a recovery from myasthenic symptoms. These results suggest that passive transfer of the appropriate anti-idiotypes may have potential in the regulation of myasthenia.This publication has 5 references indexed in Scilit:
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