SIMILARITY BETWEEN RECEPTORS RESPONSIBLE FOR THE PRODUCTION OF ANALGESIA AND LENTICULAR OPACITY
Open Access
- 1 December 1961
- journal article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 17 (3) , 433-441
- https://doi.org/10.1111/j.1476-5381.1961.tb01130.x
Abstract
Evidence is presented that the receptors responsible for the mediation of analgesia by morphine-like drugs are similar to those which are involved in the production of a reversible lenticular opacity. The activity of a number of compounds in mice on the lens was closely correlated with analgesic potency in this species. Stereospecificity for isomers with d configuration was demonstrated for both effects. Nalorphine only antagonized the lenticular opacity activity of those drugs the analgesic action of which it abolished.Keywords
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