Accumulation of autoreactive effector T cells and allo-specific regulatory T cells in the pancreas allograft of a type 1 diabetic recipient
- 23 December 2008
- journal article
- case report
- Published by Springer Nature in Diabetologia
- Vol. 52 (3) , 494-503
- https://doi.org/10.1007/s00125-008-1237-z
Abstract
Simultaneous kidney–pancreas transplantation is an established treatment for patients with type 1 diabetes and end-stage renal failure, even though restored beta cell function may become affected by recurrent islet autoimmunity or graft rejection. We characterised infiltrating lymphocytes isolated from a pancreatic graft with normal endocrine function in a kidney–pancreas recipient with type 1 diabetes.Keywords
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