Haemoglobin D β Los Angeles (D Punjab, α2β2 121 Glu NH2) in a Thai Family
- 1 January 1968
- journal article
- research article
- Published by S. Karger AG in Acta Haematologica
- Vol. 39 (3) , 151-158
- https://doi.org/10.1159/000208955
Abstract
A nonsickling abnormal hemoglobin moving between hemoglobins F and A2 in electrophoreses at pH 8.6 was found in a Thai family. Chemical analysis revealed that it was [alpha]2[beta]2 121Glu NH2 which is identical with hemoglobin D Punjab or D [beta] Los Angeles. Five persons were heterozygous for this hemoglobin; hemoglobin D constituted 36-40% and, except for 1 person with superimposed Fe deficiency, the hemato- logical findings including the levels of hemoglobins A2 and F were normal. It is the 1st detection of hemoglobin D in Thailand after several thousands of samples having been examined by starch gel electro-phoresis.This publication has 12 references indexed in Scilit:
- Abnormal human haemoglobins: I. The comparison of normal human and sickle-cell haemoglobins by “fingerprinting”Published by Elsevier ,2003
- Hemoglobin S-D DiseaseAnnals of Internal Medicine, 1966
- Abnormal human haemoglobins VII. The comparison of normal human haemoglobin and haemoglobin DChicagoBiochimica et Biophysica Acta, 1961
- An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individualsBiochemical Journal, 1959
- SICKLE CELL-HEMOGLOBIN D DISEASEAnnals of Internal Medicine, 1959
- The Hemoglobin D SyndromesBlood, 1958
- On the Prevalence of Hemoglobin D in the American NegroBlood, 1956
- Clinical Manifestations of Inherited Abnormal HemoglobinsBlood, 1955
- Bound Iron and Unsaturated Iron-binding Capacity of Serum; Rapid and Reliable Quantitative DeterminationExperimental Biology and Medicine, 1954
- Studies on Abnormal HemoglobinsBlood, 1951