Effect of multiple time point sampling on the sensitivity of the dexamethasone suppression test

Abstract
Dexamethasone suppression test sensitivity in 188 patients [with possible major affective disorder] was 61.6% when cortisol was measured at 6 time points and 48.5% when cortisol was measured twice. More patients had abnormal cortisol levels at 2000 h than at 1600 or 2200 h.

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