Genetic Control of Immune Responsiveness in Man1

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Abstract
Interest in immunogenetics originated from 2 streams: histocompatibility in mouse and man, and inheritance of specific immune responses in the guinea pig and mouse. In the mouse, there are genes associated with the major histocompatibility complex (MHC) which code for antigens determining allograft responses and mixed lymphocyte reactions, control responses to certain antigens (Ir genes) and code for cell-surface antigens which elicit specific antisera (anti-Ia). In man there is genetic control, in part X-linked, over levels of immunoglobulins and immunoglobulin classes. Evidence for MHC-linked genetic control is derived from immune responses to micro-organisms, pollen antigens, food antigens, vaccines, innocuous test antigens and autoantigens. Some evidence exists for allotype-linked genetic control. Practical aspects concern influences of the MHC on susceptibility to disease within individuals and populations.