Anomalous Effects of Certain Preparations of Desiccated Thyroid on Serum Protein-Bound Iodine

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Abstract
MEASUREMENT of the concentration of protein-bound iodine (PBI) in the serum is perhaps the single most reliable laboratory method in the diagnosis of thyrotoxicosis or hypothyroidism and is also of great value as an indication of the adequacy of treatment in these disorders. In the treatment of myxedema, however, it is recognized that the concentration of the PBI associated with restoration of a normal metabolic state depends upon the particular thyroid hormone employed. Thyroxine (T4) and L-3,5,3′-tri-iodothyronine (T3), both natural products of thyroidal secretion, differ widely in this respect. T3, a highly potent hormone . . .