Selectivity-Enhancement of Hydrolase Reactions
- 1 January 1993
- journal article
- research article
- Published by Taylor & Francis in Biocatalysis
- Vol. 8 (2) , 91-132
- https://doi.org/10.3109/10242429308998200
Abstract
This review pinpoints the strategies which can be employed to improve the enantio- and diasteroselectivity of hydrolytic enzymes, i.e. esterases, proteases, and lipases. The influence of variations of reactants, — enzyme and substrate — and conditions — kinetics, medium, temperature, pH — on the chiral recognition process of the enzyme is discussed with examples from the recent literature.Keywords
This publication has 126 references indexed in Scilit:
- Resolution of racemic carboxylic acids via the lipasecatalyzed irreversible transesterification using vinyl esters; Effects of alcohols as nucleophiles and organic solvents on enantioselectivityBiotechnology Letters, 1992
- Lipase-catalyzed transesterification procedure for the resolution of non-protein amino acidsBiotechnology Letters, 1992
- Solvent-induced inversion of enantiosflectivity in lipase-catalyzed esterification of 2-phenoxypropionic acidsBiotechnology Letters, 1992
- Resolution of mandelic acids by lipase-catalysed transesterifications in organic media: inversion of enantioselectivity mediated by the acyl donorJournal of the Chemical Society, Perkin Transactions 1, 1992
- Enzymatic hydrolysis of 2,2,2,-trifluoroethyl ?-chloro-?-phenylacetate in organic mediaBiotechnology Letters, 1991
- Lipase-catalyzed stereoselective thiotransesterification of mercapto estersThe Journal of Organic Chemistry, 1990
- Sequential biocatalytic kinetic resolutionsJournal of the American Chemical Society, 1990
- Enzyme-catalysed inter-esterification procedure for the preparation of esters of a chiral secondary alcohol in high enantiomeric purityJournal of the Chemical Society, Chemical Communications, 1990
- Highly enantioselective route to (R)-proline derivatives via enzyme catalysed hydrolysis of cis-N-benzyl-2,5-bismethoxycarbonylpyrrolidine in an aqueous dimethyl sulphoxide mediumJournal of the Chemical Society, Chemical Communications, 1987
- Über den Einfluß von optisch aktiven Fremdstoffen auf die Konfigurations‐Spezifität der Leber‐Esterase verschiedener Tiere. (Dritte) Mitteilung „Über asymmetrische Ester‐Hydrolyse durch Enzyme”︁ in der von R. Willstätter, R. Kuhn und E. Bamann begonnenen UntersuchungsreiheBerichte der deutschen chemischen Gesellschaft (A and B Series), 1930