A theoretical study of quantitative flow measurements with constant infusion of short-lived isotopes

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Abstract
Recent developments in the technique of constant infusion and in emission computed tomography created a new method for quantitative regional flow measurements. The theoretical relationship between flow and radioactivity during constant infusion of short-lived isotopes is reexamined. Sensitivity analysis is used to assess the accuracy of the method. Selection of a half-life [t1/2] to meet accuracy requirements is discussed. A method for the determination of the distribution volume of the tracer is proposed.