Relationship of Pyridoxine Deficiency to Adrenal Function in Production of Leucocytes in Mice.

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Abstract
Previous work has shown that pyridoxine deficiency induced in mice by feeding desoxypyridoxine HC1 causes granulocytosis, lymphopenia and myeloid metaplasia in the spleen. Entirely similar changes occur when mice are treated with cortisone. Expts. designed to determine the relationship between pyridoxine deficiency and adrenal function gave the following results: (1) In adrenalectomized mice pyridoxine deficiency causes the same hematologic changes as in normal animals indicating that the effect of pyridoxine deficiency is not mediated through the adrenal cortex. (2) In pyridoxine-deficient mice, treatment with cortisone produces a summation of hematologic effect. The granulocytosis and lymphopenia are more marked than with pyridoxine deficiency alone or cortisone treatment above. (3) The hematologic effect of cortisone treatment cannot be prevented by the admn. of large amts. of pyridoxine, pyridoxal, and pyridoxamine. It is con-cluded that a relationship between the hematologic effect of pyridoxine deficiency and that of cortisone treatment has not been demonstrated.