Use of Two Vaccines (Live G30D or Killed RW16) in the Prevention of Salmonella typhimurium Infections in Chickens

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Abstract
Several properties of a galactose epimerase mutant strain (G3OD) of S. typhimurium were investigated in white leghorn and white rock chickens. More chickens shed G3OD when it was administered orally at 1 day of age than when given at 1, 2 or 4 wk of age. Mean cumulative data obtained for 52 days on the shedding rate of virulent RW16 in unvaccinated challenged controls were significantly higher (P < 0.05) than data in challenged groups that had been vaccinated s.c. with live G3OD. Chickens vaccinated twice with live G3OD or killed RW16 were less likely to shed RW16 than unvaccinated controls following challenge with live RW16. Vaccination with live G3OD and killed RW16 was significantly more beneficial (P < 0.05) than using either vaccine alone twice. The administration route of the vaccines made no difference in the reduction of shedding.

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