THE EPIDEMIOLOGY OF ACUTE RESPIRATORY INFECTIONS CONDITIONED BY SULFONAMIDES.

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Abstract
Under prolonged sulfadiazine adm. in physically normal children, pneumococcal types may acquire a high degree of resistance to the drug. With resistance, there is a striking shift in predominance of types due to elimination of strains not so readily becoming fast. Despite their fastness, the strains retain their virulence and specificity. With discontinuation of drug treatment, the incidence of types tends towards a more normal distribution. Precipitating, agglutinating and protective antibodies were not found in either treated or untreated children. Lack of clinical infection by virulent carrier types was frequently unrelated to either drug treatment or detectable circulating antibody.