Basal and Stimulated Calcitonin Secretion in Primary Hyperparathyroidism before and after Parathyroidectomy
- 1 January 1986
- journal article
- research article
- Published by S. Karger AG in Hormone Research
- Vol. 23 (3) , 142-146
- https://doi.org/10.1159/000180309
Abstract
To investigate calcitonin secretion in primary hyperparathyroidism, basal and stimulated (3 mg Ca++/kg body weight/10 min) immunoreactive calcitonin plasma levels were studied before parathyroidectomy. Plasma calcitonin levels were raised in 50% of patients regardless of sex, but a significant correlation between basal plasma calcium and calcitonin was found only in males. A reduced calcitonin response to calcium infusion was observed in all patients. Parathyroidectomy invariably induced a normalization of calcitonin basal levels. Our findings confirm the existence of a decreased parafollicular cell reserve probably as a consequence of the persistent hypercalcemic state in hyperparathyroid patients and suggest that it is more frequent in females.Keywords
This publication has 9 references indexed in Scilit:
- A calcium clamp technique in manActa Physiologica Scandinavica, 1983
- Plasma Calcitonin and TumorsTumori Journal, 1983
- An Estimate of the Endogenous Secretion Rate of Calcitonin in ManClinical Science, 1982
- CALCITONIN SECRETION AND BONE DISEASE SEVERITY IN HYPERCALCAEMIC HYPERPARATHYROIDISMClinical Endocrinology, 1981
- Limited calcitonin reserve in hyperparathyroidismThe Lancet Healthy Longevity, 1980
- Calcitonin Secretion in Primary Hyperparathyroidism*Journal of Clinical Endocrinology & Metabolism, 1979
- Pre- and Postoperative Studies of Plasma Calcitonin in Primary HyperparathyroidismJournal of Clinical Investigation, 1979
- Calcitonin Secretion in Normal Human Subjects*Journal of Clinical Endocrinology & Metabolism, 1978
- NORMAL PLASMA CALCITONIN: CIRCADIAN VARIATION AND RESPONSE TO STIMULIClinical Endocrinology, 1977